"The truth of the human condition is that everyone lies. The only variable is about what."

Dr. Gregory House or House as we know him, the misanthrope, anarchist, vindictive, arroganthead of Department of Diagnostic Medicine at Princeton-Plainsboro Teaching Hospital where he is mostly assisted by a team of 3 doctors with whom he is often rude, constantly taunting and interfering in their personal lives; he barely spends any time meeting his patients as he believes that sick people always lie which gets in way of his diagnosing the actual problem, he tries to avoid meeting his patients at all and delegates this unimportant chore to his team, however when he does meet his patients, he has been shown to display a terrible bedside manner as he hardly follows any ethical considerations of his profession beingfilled with eternally blunt, acerbic and sarcastic speech.

One might even say, the guy is a RAPID FIRE QUOTE MACHINE.

House is always prepared to take up cases that everyone else has given up on,  and has a ready urge to perform risky tests and use unconventional, idiosyncratic methods of treatment, this tendency of high risk behavior, also extends to himself as he is frequently seen in the series conducting various medical experiments on himself, excessively abusing vicodin, trying LSD, faking brain cancer, getting hypnotized and overdosing on Alzheimer’s medication amongst many others;

It has been stated by Wilson, that House has Rubik’s Complex, it is the PUZZLE which matters more to him, than the patient’s life, i.e. he is more concerned with figuring out the problem rather than treating it, so at times he continues to diagnose patients even after they are dead, however on other occasions his obsession for solving the puzzle results in solutions even in dreary health conditions, when the patient has no chance of surviving often leading to a miraculous recovery of a passing life.

He flouts rules, openly disregarding authority and perpetually asking his team to break into the house of his patients to gather information about them, he doesn’t only weigh the scientific aspect of a diagnosis but also the complexity of the patient’s emotional status.

Surprisingly this supposed selfish, self-absorbed and egocentric in the last season fakes his own death to spend Wilson’s last five months with him; Wilson asks House about what they will do when his cancer gets bad, but House simply tells him that "cancer is boring".